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Journal Cover

Cucurbit[7]uril inhibits islet amyloid polypeptide aggregation by targeting N terminus hot segments and attenuates cytotoxicity

 publications

L. Palanikumar*, Kalmouni, M., Houhou, T., Abdullah, O., Ali, L., Pasricha, R., Straubinger, R., Thomas, S., Afzal, A.J., Barrera, F.N. & Magzoub, M.* (2023) pH-responsive upconversion mesoporous silica nanospheres for combined multimodal diagnostic imaging and targeted photodynamic and photothermal cancer therapy. ACS Nano 19, 18979–18999. 

https://doi.org/10.1021/acsnano.3c04564

Selected as a Cover Article.

Press coverage (Arabic)Al KhaleejMena FNNabdMasr Al YoumHead TopicsUAE News AppEmirate Press7enews

Press coverage (English)Khaleej TimesGulf NewsReuters​, ZawyaZawya2WAMEmirati NewsMSNWired7enewsARN News CenterBig News NetworkTech MagazineThe Print

Behind the Paper: Kalmouni, M., L. Palanikumar & Magzoub, M. (2024) pH-responsive upconversion mesoporous silica nanospheres for enhanced phototherapy. Nature Cancer Research Community.

 

Venit, T., Sapkota, O., Abdrabou, W.S., Loganathan, P., Pasricha, R., Mahmood, S.R., El Said, N.H., Sherif, S., Thomas, S., Abdelrazig, S., Amin, S., Bedognetti, D., Idaghdour, Y., Magzoub, M. & Percipalle P. (2023) Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice. Nat. Commun. 14, 6328. 

https://doi.org/10.1038/s41467-023-42093-w

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Maity, D., Oh, Y., Gremer, L., Hoyer, W., Magzoub, M. & Hamilton, A.D. (2022) Cucurbit[7]uril inhibits IAPP aggregation by targeting N-terminus hot segments. Chem. Eur. J. 28,  e2022004. 

https://doi.org/10.1002/chem.202200456

Selected as a Cover Article.

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L. Palanikumar, Karpauskaite, L., Al-Sayegh, M., Alam, M., Chehade, I., Hassan, S., Maity, D., Ali, L., Falls, Z., Samudrala, R., Kalmouni, M., Hunashal, Y., Ahmed, J., Houhou, T., Karapetyan, S., Pasricha, R., Esposito, G., Afzal, A.J., Hamilton, A.D.*, Kumar, S.* & Magzoub, M.* (2021) Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat. Commun. 12, 3962. https://doi.org/10.1038/s41467-021-23985-1

Press coverage (Arabic)WAM, Al Ittihad, Al Khaleej, Al Bayan, Al Roeya, Al Fajr, Al Wahda, AlWatan, Nabd1, Nabd2, Head Topics, Gulf Tourism, UrduPoint

Presscoverage (English): The NationalWAMZawya,  UrduPoint,  Archyde, Eurek Alert, ScienMag

Behind the Paper: Kalmouni, M., L. Palanikumar & Magzoub, M. (2021) A functional bridge: amyloid inhibitors and cancer. Nature Cancer Research Community.

Maity, D., Howarth, M., Vogel, M.C., Magzoub, M. & Hamilton, A.D. (2021) Peptidomimetic-based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity. J. Am. Chem. Soc. 143, 3086–3093. 

https://doi.org/10.1021/jacs.0c09967

Selected as a Cover Article.

Alam, M., Tahir, J., Siddiqui, A., Magzoub, M., Shahzad-ul-Hussan, S., Mackey, D. & Afzal, A.J. (2021) RIN4 homologs from important crop species differentially regulate the Arabidopsis NB-LRR immune receptor, RPS2. Plant Cell Rep. 40, 2341–2356. 

https://doi.org/10.1007/s00299-021-02771-9

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Maity, D., Kumar, S., AlHussein, R., Gremer, L., Howarth, M., Karpauskaite, L., Hoyer, W., Magzoub, M. & Hamilton, A.D. (2020) Sub-stoichiometric inhibition of IAPP aggregation: A peptidomimetic approach to anti-amyloid agents. RSC Chem. Biol. 1, 225-232.

https://doi.org/10.1039/D0CB00086H

Selected as a Hot Article.

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L. Palanikumar, Al-Hosani, S., Kalmouni, M., Saleh, H. & Magzoub, M.* (2020) Hexokinase II-derived cell-penetrating peptide mediates delivery of microRNA mimic for cancer-selective cytotoxicity. Biochemistry 59, 2259−2273.

https://doi.org/10.1021/acs.biochem.0c00141

Behind the Paper: Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M.* (2020) Hexokinase II-derived cancer targeting peptide: a novel strategy to combat cancer. Nature Cancer Research Community.

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Magzoub, M. (2020) Combating proteins with proteins: Engineering cell-penetrating peptide antagonists of amyloid-β aggregation and associated neurotoxicity. DNA Cell Biol. 39, 920–925. 

https://doi.org/10.1089/dna.2020.5604

Selected as a Cover Article.

L. Palanikumar, Al-Hosani, S., Kalmouni, M., Nguyen, V.P., Ali, L., Pasricha, R., Barrera, F.N. & Magzoub, M.* (2020) pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. Biol. 3, 95. 

https://doi.org/10.1038/s42003-020-0817-4

Selected as a Research Highlight.

Highlighted in the editorial 'Setting out on a fantastic voyage to advance nanomedicine'. 

Press coverage (Arabic): 24.ae, Al Bayan, Al Fajr, Al IttihadAl Khaleej, Al Roeya

Press coverage (English): EurekAlert, The NationalAbu Dhabi City GuideecancerEuropean Pharmaceutical Review, ExpatmediaInnovators MagazineMedical XpressNews Medical, Science Codex, Zawya

Behind the Paper: Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M. (2020) Exploiting the unique properties of tumors to deliver chemotherapeutics to cancer cells. Nature Cancer Research Community.

Sharma, S.K.S., Al-Hosani, S., Kalmouni, M., Nair, A.R., Palanikumar, L., Pasricha, R., Sadler, K.C., Magzoub, M. & Jagannathan, R. (2020) Supercritical CO2 processing generates aqueous cisplatin with enhanced cancer specificity. ACS Omega 5, 4558−4567. 

https://doi.org/10.1021/acsomega.9b03917

Henning-Knechtel, A., Kumar, S., Wallin, C., Król, S., Wärmländer, S., Jarvet, J., Esposito, G., Kirmizialtin, A., Gräslund, A., Hamilton, A.D. & Magzoub, M.* (2020) Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity. Cell Rep. Phys. Sci. 1,100014.

https://doi.org/10.1016/j.xcrp.2020.100014

Presss Coverage (Arabic): 24.aeAkhbarakAl BayanAl FajrAl IttihadAl KhaleejAl ShabibaGulf365MenaFnRadaar NewsSynar

Press coverage (English): EurekAlert,  Nature Middle East,  The National,  Dubai PR NetworkGo DubaiGulf TodayMedical XpressThe National Tribune, Zawya

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Pansieri, J., Ostojić, L., Iashchishyn, I.A., Magzoub, M., Wallin, C., Wärmländer, S., Gräslund, A., Ngoc, M.N., Smirnovas, V., Svedruzic, Z. & Morozova-Roche, L.A. (2019) Pro-inflammatory S100A9 protein aggregation promoted by NCAM1 peptide constructs. ACS Chem. Biol. 14, 1410−1417. 

https://doi.org/10.1021/acschembio.9b00394

Kalmouni, M., Al Hosani, S. & Magzoub, M.* (2019) Cancer targeting peptides. Cell Mol. Life Sci. 76, 2171-2183.

https://doi.org/10.1007/s00018-019-03061-0

Nguyen, V.P., L. Palanikumar, Kennel, S.J., Ye, Y., Alves, D.S., Wall, J.S., Magzoub, M. & Barrera, F.N. (2019) Mechanistic insights into the pH-dependent membrane peptide ATRAM. J. Control. Release 298, 142-153.

https://doi.org/10.1016/j.jconrel.2019.02.010

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Kumar, S.*, Henning-Knechtel, A., Magzoub, M.* & Hamilton, A.D.* (2018) Peptidomimetic-based multi-domain targeting offers critical evaluation of Aβ structure and toxic function. J. Am. Chem. Soc. 140, 6562–6574.

https://doi.org/10.1021/jacs.7b13401

Yanez, A., Desta, I., Commins, P., Magzoub, M. & Naumov, P. (2018) Morphokinematics of the hygroactuation of feather grass awns. Adv. Biosyst. 2, 1800007.

https://doi.org/10.1002/adbi.201800007

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Henning-Knechtel, A., Knechtel, J. & Magzoub, M.* (2017) DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels. Nucleic Acids Res. 45, 12057-12068.

https://doi.org/10.1093/nar/gkx990

Selected as a Breakthrough Article.

Selected as a Cover Article.

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Kumar, S., Henning-Knechtel, A., Chehade, I., Magzoub, M. & Hamilton, A.D. (2017) Foldamer-mediated structural rearrangement attenuates Aβ oligomerization and cytotoxicity. J. Am. Chem. Soc. 139, 17098-17108.

https://doi.org/10.1021/jacs.7b08259

Selected as a Cover Article.

Woldetsadik, A.D., Sharma, S.K., Khapli, S., Jagannathan, R.* & Magzoub, M.* (2017) Hierarchically porous calcium carbonate scaffolds for bone tissue engineering. ACS Biomater. Sci. Eng. 32457–2469.

https://doi.org/10.1021/acsbiomaterials.7b00301

 

Benyettou, F., Fahs, H., Elkharrag, R., Bilbeisi, R.A., Asma, B., Rezgui, R., Motte, L., Magzoub, M., Brandel, J., Olsen, J.-C., Piano, F., Gunsalus, K., Platas-Iglesias, C. & Trabolsi, A. (2017) Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. RSC Adv. 7, 23827–23834.

https://doi.org/10.1039/C7RA02693E

Woldetsadik, A.D., Vogel, M.C., Rabeh, W.M. & Magzoub, M.* (2017) Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells. FASEB J., 31, 2168-2184.

https://doi.org/10.1096/fj.201601173R

Sharma, S.K., Woldetsadik, A.D., Blanton, T., O’Connor, M.J., Magzoub, M.* & Jagannathan, R.* (2017) Production of nanostructured molecular liquids by supercritical CO2 processing. OpenNano 2, 9-18.

https://doi.org/10.1016/j.onano.2016.11.001

Mukundan, V., Maksoudian, C., Vogel, M.C., Chehade, I., Katsiotis, M.S., Alhassan, S.M. & Magzoub, M.* (2017) Cytotoxicity of prion protein-derived cell-penetrating peptides is modulated by pH but independent of amyloid formation. Archives Biochem. Biophys613, 31-42.

https://doi.org/10.1016/j.abb.2016.11.001 

Recommended as an F1000Prime Article.

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Rezgui, R., Blumer, K., Yeoh-Tan, G., Trexler, A.J. & Magzoub, M. (2016) Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy. Biochim. Biophys. Acta 1858, 1499-1506.

https://doi.org/10.1016/j.bbamem.2016.03.023

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Kulikov, O.V., Kumar, S., Magzoub, M., Knipe, P.C., Saraogi, I., Thompson, S., Miranker, A.D. & Hamilton, A.D. (2015) Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation. Tetrahedron Lett. 56, 3760-3673.

https://doi.org/10.1016/j.tetlet.2015.02.132

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For a full list of publications, please visit this link.

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Phone: +971 2 628 4760

Fax:       +971 2 659 0791

Magzoub Lab

Experimental Research Building (ERB)

NYU Abu Dhabi

Saadiyat Island Campus

P.O. Box 129188

Abu Dhabi, United Arab Emirates

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