The Magzoub Lab is part of the Biology Program at NYU Abu Dhabi.

Journal Covers

Publications

2019

Kalmouni, M., Al Hosani, S. & Magzoub, M. Cancer Targeting Peptides. Cell Mol. Life Sci., in press.

Nguyen, V.P., Palanikumar, L., Kennel, S.J., Ye, Y., Alves, D.S., Wall, J.S., Magzoub, M. & Barrera, F.N. Mechanistic insights into the pH-dependent membrane peptide ATRAM. J. Control. Release 298, 142-153.

2018

Kumar, S.*, Henning-Knechtel, A., Magzoub, M.* & Hamilton, A.D.* Peptidomimetic-based multi-domain targeting offers critical evaluation of Aβ structure and toxic function. J. Am. Chem. Soc. 140, 6562–6574.

Yanez, A., Desta, I., Commins, P., Magzoub, M. & Naumov, P. Morphokinematics of the hygroactuation of feather grass awns. Adv. Biosyst. 2, 1800007.

2017

Henning-Knechtel, A., Knechtel, J. & Magzoub, M.* DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels. Nucleic Acids Res. 45, 12057-12068.

Selected as a Breakthrough Article and a Cover Article.

Kumar, S., Henning-Knechtel, A., Chehade, I., Magzoub, M. & Hamilton, A.D. Foldamer-mediated structural rearrangement attenuates Aβ oligomerization and cytotoxicity. J. Am. Chem. Soc. 139, 17098-17108.

Selected as a Cover Article.

Woldetsadik, A.D., Sharma, S.K., Khapli, S., Jagannathan, R.* & Magzoub, M.* Hierarchically porous calcium carbonate scaffolds for bone tissue engineering. ACS Biomater. Sci. Eng. 32457–2469.

 

Benyettou, F., Fahs, H., Elkharrag, R., Bilbeisi, R.A., Asma, B., Rezgui, R., Motte, L., Magzoub, M., Brandel, J., Olsen, J.-C., Piano, F., Gunsalus, K., Platas-Iglesias, C. & Trabolsi, A. Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. RSC Adv. 7, 23827–23834.

Woldetsadik, A.D., Vogel, M.C., Rabeh, W.M. & Magzoub, M.* Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells. FASEB J., 31, 2168-2184.

Sharma, S.K., Woldetsadik, A.D., Blanton, T., O’Connor, M.J., Magzoub, M.* & Jagannathan, R.* Production of nanostructured molecular liquids by supercritical CO2 processing. OpenNano 2, 9-18.

 

Mukundan, V., Maksoudian, C., Vogel, M.C., Chehade, I., Katsiotis, M.S., Alhassan, S.M. & Magzoub, M.* Cytotoxicity of prion protein-derived cell-penetrating peptides is modulated by pH but independent of amyloid formation. Archives Biochem. Biophys613, 31-42. 

Recommended as an F1000Prime Article.

2016

Rezgui, R., Blumer, K., Yeoh-Tan, G., Trexler, A.J. & Magzoub, M. Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy. Biochim. Biophys. Acta 1858, 1499-1506.

2015

Benyettou, F., Rezgui, R., Ravaux, F., Jaber, T., Blumer, K., Jouiad, M., Motte, L., Olsen, J.-C., Platas-Iglesias, C., Magzoub, M. & Trabolsi, A. Synthesis of silver nanoparticles for the dual delivery of doxorubicin and alendronate to cancer cells. J. Mater. Chem. B 3, 7237-7245.

 

Kulikov, O.V., Kumar, S., Magzoub, M., Knipe, P.C., Saraogi, I., Thompson, S., Miranker, A.D. & Hamilton, A.D. (2015) Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation. Tetrahedron Lett. 56, 3760-3673.

2014

Hebda, J., Magzoub, M. & Miranker, A.D. Small molecule screening in context: Lipid-catalyzed amyloid formation. Protein Sci. 23, 1341-1348.

2012

Magzoub, M. & Miranker, A.D.  Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide. FASEB J. 26, 1228-1238.

2011

Magzoub, M. & Miranker, A.D. p53 succumbs to peer pressure. Nat. Chem. Biol. 7, 248-249.

2009

Hebda, J.A., Saraogi, I., Magzoub, M., Hamilton, A.D. & Miranker, A.D. A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chem. Biol. 16, 943-950.

 

Magzoub, M., Zhang, H., Dix, J.A. & Verkman, A.S. Extracellular space volume measured by two-color pulsed dye injection with microfiberoptic fluorescence photodetection. Biophys. J. 96, 2382–2390.

2008

Zador, Z., Magzoub, M., Jin, S., Manley, G.T., Papadopoulos, M.C. & Verkman, A.S. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space in brain. FASEB J. 22, 870-879.

 

Magzoub, M., Jin, S. & Verkman, A.S. Enhancement of macromolecule diffusion deep in tumors following enzymatic degradation of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 22, 276-284.

 

Oglecka K., Lundberg, P., Magzoub, M., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects. Biochim. Biophys. Acta 1778, 206-213.

2006

Magzoub, M., Padmawar, P., Dix, J.A. & Verkman, A.S. Millisecond association kinetics of K+ with Triazacryptand-based K+ indicators measured with fluorescence correlation spectroscopy. J. Phys. Chem. B 110, 21216-21221.

 

Magzoub, M., Sandgren, S., Lundberg, P., Oglecka, K., Lilja, J., Wittrup, A., Eriksson, L.E.G., Langel, Ü., Belting, M. & Gräslund, A.  N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis. Biochem. Biophys. Res. Commun. 348, 379-385.

 

Thiagarajah, J.R., Kim, J.K., Magzoub, M. & Verkman, A.S. Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nat. Methods 3, 275-280.

 

Magzoub, M., Gräslund, A. & Pramanik, A. Characterization of prion-derived cell-penetrating peptides in cellular and model membrane systems. In Biochemistry and Biophysics of Lipids (Pramanik, A., ed), pp. 175-192, Transworld Research Network, Kerala.

2005

Magzoub, M., Pramanik, A. & Gräslund, A. Modelling the endosomal escape of cell-penetrating peptides: transmembrane pH gradient driven translocation across phospholipid bilayers. Biochemistry 44, 14890-14897.

 

Magzoub, M., Oglecka, K., Pramanik, A., Eriksson, L.E.G. & Gräslund, A. Membrane perturbation effects by peptides derived from the N-termini of prion proteins. Biochim. Biophys. Acta 1716, 126-136.

2004

Magzoub, M. & Gräslund, A. Cell-penetrating peptides: from inception to application. Q. Rev. Biophys. 37, 147-195.

2003

Magzoub, M., Eriksson, L.E.G. & Gräslund, A. Comparison of the interaction, positioning, structure induction and membrane perturbation of cell-penetrating peptides and non-translocating variants with phospholipid vesicles. Biophys. Chem. 103, 271-288.

2002

Lundberg, P., Magzoub, M., Lindberg, M., Hällbrink, M., Jarvet, J., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Cell membrane translocation of the N-terminal (1-28) part of the prion protein. Biochem. Biophys. Res. Commun. 299, 85-90.

 

Magzoub, M., Eriksson, L.E.G. & Gräslund, A. Conformational states of the cell-penetrating peptide penetratin when interacting with phospholipids vesicles:  effects of surface charge and peptide concentration. Biochim. Biophys. Acta 1563, 53-63.

2001

Kilk, K., Magzoub, M., Pooga, M., Eriksson, L.E.G. Langel, Ü. & Gräslund, A. Cellular internalization of a cargo complex with a novel peptide derived from the third helix of the islet-1 homeodomain. Comparison with the penetratin peptide. Bioconjug. Chem. 12, 911-916.

 

Magzoub, M., Kilk, K., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles. Biochim. Biophys. Acta 1516, 77-89.