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Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity




Maity, D., Oh, Y., Gremer, L., Hoyer, W., Magzoub, M., Hamilton, A.D. Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity. Chemistry,


L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nature Communications12

Press coverage: The National, EurekAlert, Emirates News Agency, NYU Abu Dhabi, Gulf Today

Debabrata, M., Howarth, M., Vogel, M.C., Magzoub, M., Hamilton, A.​, Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity. J. Am. Chem. Soc. ,

Selected as a Cover Article


L. Palanikumar, Karpauskaite, L., Hassan, S., Alam, M., Al-Sayegh, M., Chehade, I., Maity, D., Ali, L., Falls, Z., Samudrala, R., Kalmouni, M., Hunashal, Y., Ahmed, J.,  Karapetyan, S., Pasricha, R., Esposito, G., Afzal, A.J., Hamilton, A.D.*, Kumar, S.* & Magzoub, M.* Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. bioRxiv.

Maity, D., Kumar, S., AlHussein, R., Gremer, L., Howarth, M., Karpauskaite, L., Hoyer, W., Magzoub, M. & Hamilton, A.D. Sub-stoichiometric inhibition of IAPP aggregation: A peptidomimetic approach to anti-amyloid agents. RSC Chem. Biol., in press.

Selected as a Cover Article.

Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M.* Hexokinase II-derived cancer targeting peptide: a novel strategy to combat cancer. Nature Cancer Research Community.

L. Palanikumar, Al-Hosani, S., Kalmouni, M., Saleh, H. & Magzoub, M.* Hexokinase II-derived cell-penetrating peptide mediates delivery of microRNA mimic for cancer-selective cytotoxicity. Biochemistry 59, 2259−2273.

Magzoub, M. Combating proteins with proteins: Engineering cell-penetrating peptide antagonists of amyloid-β aggregation and associated neurotoxicity. DNA Cell Biol. 39, 920–925.

Selected as a Cover Article.

Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M. Exploiting the unique properties of tumors to deliver chemotherapeutics to cancer cells. Nature Cancer Research Community.


L. Palanikumar, Al-Hosani, S., Kalmouni, M., Nguyen, V.P., Ali, L., Pasricha, R., Barrera, F.N. & Magzoub, M.* pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. Biol. 3, 95.

Selected as a Research Highlight and a Cover Article.

Highlighted in the editorial "Setting out on a fantastic voyage to advance nanomedicine".

Sharma, S.K.S., Al-Hosani, S., Kalmouni, M., Nair, A.R., Palanikumar, L., Pasricha, R., Sadler, K.C., Magzoub, M. & Jagannathan, R. Supercritical CO2 processing generates aqueous cisplatin with enhanced cancer specificity. ACS Omega 5, 4558−4567

Henning-Knechtel, A., Kumar, S., Wallin, C., Król, S., Wärmländer, S., Jarvet, J., Esposito, G., Kirmizialtin, A., Gräslund, A., Hamilton, A.D. & Magzoub, M.* Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity. Cell Rep. Phys. Sci. 1,100014.


Kumar, S., Hamilton, A.D., Magzoub, M., Hassan, S. Use of oligopyridylamides to inhibit mutant p53 amyloid formation and restore its tumor suppressor function. US Patent 10,500,197.


Pansieri, J., Ostojić, L., Iashchishyn, I.A., Magzoub, M., Wallin, C., Wärmländer, S., Gräslund, A., Ngoc, M.N., Smirnovas, V., Svedruzic, Z. & Morozova-Roche, L.A. (2019) Pro-inflammatory S100A9 protein aggregation promoted by NCAM1 peptide constructs. ACS Chem. Biol. 14, 1410−1417. 

Kalmouni, M., Al Hosani, S. & Magzoub, M.* Cancer targeting peptides. Cell Mol. Life Sci. 76, 2171-2183.

Nguyen, V.P., L. Palanikumar, Kennel, S.J., Ye, Y., Alves, D.S., Wall, J.S., Magzoub, M. & Barrera, F.N. Mechanistic insights into the pH-dependent membrane peptide ATRAM. J. Control. Release 298, 142-153.


Kumar, S.*, Henning-Knechtel, A., Magzoub, M.* & Hamilton, A.D.* Peptidomimetic-based multi-domain targeting offers critical evaluation of Aβ structure and toxic function. J. Am. Chem. Soc. 140, 6562–6574.

Yanez, A., Desta, I., Commins, P., Magzoub, M. & Naumov, P. Morphokinematics of the hygroactuation of feather grass awns. Adv. Biosyst. 2, 1800007.


Henning-Knechtel, A., Knechtel, J. & Magzoub, M.* DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels. Nucleic Acids Res. 45, 12057-12068.

Selected as a Breakthrough Article and a Cover Article.

Kumar, S., Henning-Knechtel, A., Chehade, I., Magzoub, M. & Hamilton, A.D. Foldamer-mediated structural rearrangement attenuates Aβ oligomerization and cytotoxicity. J. Am. Chem. Soc. 139, 17098-17108.

Selected as a Cover Article.

Woldetsadik, A.D., Sharma, S.K., Khapli, S., Jagannathan, R.* & Magzoub, M.* Hierarchically porous calcium carbonate scaffolds for bone tissue engineering. ACS Biomater. Sci. Eng. 32457–2469.


Benyettou, F., Fahs, H., Elkharrag, R., Bilbeisi, R.A., Asma, B., Rezgui, R., Motte, L., Magzoub, M., Brandel, J., Olsen, J.-C., Piano, F., Gunsalus, K., Platas-Iglesias, C. & Trabolsi, A. Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. RSC Adv. 7, 23827–23834.

Woldetsadik, A.D., Vogel, M.C., Rabeh, W.M. & Magzoub, M.* Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells. FASEB J., 31, 2168-2184.

Sharma, S.K., Woldetsadik, A.D., Blanton, T., O’Connor, M.J., Magzoub, M.* & Jagannathan, R.* Production of nanostructured molecular liquids by supercritical CO2 processing. OpenNano 2, 9-18.


Mukundan, V., Maksoudian, C., Vogel, M.C., Chehade, I., Katsiotis, M.S., Alhassan, S.M. & Magzoub, M.* Cytotoxicity of prion protein-derived cell-penetrating peptides is modulated by pH but independent of amyloid formation. Archives Biochem. Biophys613, 31-42. 

Recommended as an F1000Prime Article.


Rezgui, R., Blumer, K., Yeoh-Tan, G., Trexler, A.J. & Magzoub, M. Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy. Biochim. Biophys. Acta 1858, 1499-1506.


Benyettou, F., Rezgui, R., Ravaux, F., Jaber, T., Blumer, K., Jouiad, M., Motte, L., Olsen, J.-C., Platas-Iglesias, C., Magzoub, M. & Trabolsi, A. Synthesis of silver nanoparticles for the dual delivery of doxorubicin and alendronate to cancer cells. J. Mater. Chem. B 3, 7237-7245.


Kulikov, O.V., Kumar, S., Magzoub, M., Knipe, P.C., Saraogi, I., Thompson, S., Miranker, A.D. & Hamilton, A.D. Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation. Tetrahedron Lett. 56, 3760-3673.


Hebda, J., Magzoub, M. & Miranker, A.D. Small molecule screening in context: Lipid-catalyzed amyloid formation. Protein Sci. 23, 1341-1348.


Magzoub, M. & Miranker, A.D.  Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide. FASEB J. 26, 1228-1238.


Magzoub, M. & Miranker, A.D. p53 succumbs to peer pressure. Nat. Chem. Biol. 7, 248-249.


Hebda, J.A., Saraogi, I., Magzoub, M., Hamilton, A.D. & Miranker, A.D. A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chem. Biol. 16, 943-950.


Magzoub, M., Zhang, H., Dix, J.A. & Verkman, A.S. Extracellular space volume measured by two-color pulsed dye injection with microfiberoptic fluorescence photodetection. Biophys. J. 96, 2382–2390.


Zador, Z., Magzoub, M., Jin, S., Manley, G.T., Papadopoulos, M.C. & Verkman, A.S. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space in brain. FASEB J. 22, 870-879.


Magzoub, M., Jin, S. & Verkman, A.S. Enhancement of macromolecule diffusion deep in tumors following enzymatic degradation of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 22, 276-284.


Oglecka K., Lundberg, P., Magzoub, M., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects. Biochim. Biophys. Acta 1778, 206-213.


Magzoub, M., Padmawar, P., Dix, J.A. & Verkman, A.S. Millisecond association kinetics of K+ with Triazacryptand-based K+ indicators measured with fluorescence correlation spectroscopy. J. Phys. Chem. B 110, 21216-21221.


Magzoub, M., Sandgren, S., Lundberg, P., Oglecka, K., Lilja, J., Wittrup, A., Eriksson, L.E.G., Langel, Ü., Belting, M. & Gräslund, A.  N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis. Biochem. Biophys. Res. Commun. 348, 379-385.


Thiagarajah, J.R., Kim, J.K., Magzoub, M. & Verkman, A.S. Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nat. Methods 3, 275-280.


Magzoub, M., Gräslund, A. & Pramanik, A. Characterization of prion-derived cell-penetrating peptides in cellular and model membrane systems. In Biochemistry and Biophysics of Lipids (Pramanik, A., ed), pp. 175-192, Transworld Research Network, Kerala.


Magzoub, M., Pramanik, A. & Gräslund, A. Modelling the endosomal escape of cell-penetrating peptides: transmembrane pH gradient driven translocation across phospholipid bilayers. Biochemistry 44, 14890-14897.


Magzoub, M., Oglecka, K., Pramanik, A., Eriksson, L.E.G. & Gräslund, A. Membrane perturbation effects by peptides derived from the N-termini of prion proteins. Biochim. Biophys. Acta 1716, 126-136.


Magzoub, M. & Gräslund, A. Cell-penetrating peptides: from inception to application. Q. Rev. Biophys. 37, 147-195.


Magzoub, M., Eriksson, L.E.G. & Gräslund, A. Comparison of the interaction, positioning, structure induction and membrane perturbation of cell-penetrating peptides and non-translocating variants with phospholipid vesicles. Biophys. Chem. 103, 271-288.


Lundberg, P., Magzoub, M., Lindberg, M., Hällbrink, M., Jarvet, J., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Cell membrane translocation of the N-terminal (1-28) part of the prion protein. Biochem. Biophys. Res. Commun. 299, 85-90.


Magzoub, M., Eriksson, L.E.G. & Gräslund, A. Conformational states of the cell-penetrating peptide penetratin when interacting with phospholipids vesicles:  effects of surface charge and peptide concentration. Biochim. Biophys. Acta 1563, 53-63.


Kilk, K., Magzoub, M., Pooga, M., Eriksson, L.E.G. Langel, Ü. & Gräslund, A. Cellular internalization of a cargo complex with a novel peptide derived from the third helix of the islet-1 homeodomain. Comparison with the penetratin peptide. Bioconjug. Chem. 12, 911-916.


Magzoub, M., Kilk, K., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles. Biochim. Biophys. Acta 1516, 77-89.


Magzoub Lab

Experimental Research Building (ERB)

NYU Abu Dhabi

Saadiyat Island Campus

P.O. Box 129188

Abu Dhabi, United Arab Emirates


Phone: +971 2 628 4760

Fax: +971 2 659 07 91

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