publications
2022
Maity, D., Oh, Y., Gremer, L., Hoyer, W., Magzoub, M., Hamilton, A.D. Cucurbit[7]uril Inhibits Islet Amyloid Polypeptide Aggregation by Targeting N Terminus Hot Segments and Attenuates Cytotoxicity. Chemistry, https://doi.org/10.1002/chem.202200456
2021
L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nature Communications, 12
Press coverage: The National, EurekAlert, Emirates News Agency, NYU Abu Dhabi, Gulf Today
Debabrata, M., Howarth, M., Vogel, M.C., Magzoub, M., Hamilton, A., Peptidomimetic-Based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity. J. Am. Chem. Soc. , https://doi.org/10.1021/jacs.0c09967
Selected as a Cover Article
2020
L. Palanikumar, Karpauskaite, L., Hassan, S., Alam, M., Al-Sayegh, M., Chehade, I., Maity, D., Ali, L., Falls, Z., Samudrala, R., Kalmouni, M., Hunashal, Y., Ahmed, J., Karapetyan, S., Pasricha, R., Esposito, G., Afzal, A.J., Hamilton, A.D.*, Kumar, S.* & Magzoub, M.* Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. bioRxiv.
Maity, D., Kumar, S., AlHussein, R., Gremer, L., Howarth, M., Karpauskaite, L., Hoyer, W., Magzoub, M. & Hamilton, A.D. Sub-stoichiometric inhibition of IAPP aggregation: A peptidomimetic approach to anti-amyloid agents. RSC Chem. Biol., in press.
Selected as a Cover Article.
Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M.* Hexokinase II-derived cancer targeting peptide: a novel strategy to combat cancer. Nature Cancer Research Community.
L. Palanikumar, Al-Hosani, S., Kalmouni, M., Saleh, H. & Magzoub, M.* Hexokinase II-derived cell-penetrating peptide mediates delivery of microRNA mimic for cancer-selective cytotoxicity. Biochemistry 59, 2259−2273.
Magzoub, M. Combating proteins with proteins: Engineering cell-penetrating peptide antagonists of amyloid-β aggregation and associated neurotoxicity. DNA Cell Biol. 39, 920–925.
Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M. Exploiting the unique properties of tumors to deliver chemotherapeutics to cancer cells. Nature Cancer Research Community.
L. Palanikumar, Al-Hosani, S., Kalmouni, M., Nguyen, V.P., Ali, L., Pasricha, R., Barrera, F.N. & Magzoub, M.* pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. Biol. 3, 95.
Selected as a Research Highlight and a Cover Article.
Highlighted in the editorial "Setting out on a fantastic voyage to advance nanomedicine".
-
English language press coverage: EurekAlert, The National, Abu Dhabi City Guide, Bio Portfolio, ecancer, European Pharmaceutical Review, Expatmedia, Coding Societies, Innovators Magazine, Medical Xpress, Nature Research, Nature Research Cancer Community, News Medical, Science Codex & Zawya.
-
Arabic language press coverage: 24.ae, Al Bayan, Al Fajr, Al Ittihad, Al Khaleej & Al Roeya.
Sharma, S.K.S., Al-Hosani, S., Kalmouni, M., Nair, A.R., Palanikumar, L., Pasricha, R., Sadler, K.C., Magzoub, M. & Jagannathan, R. Supercritical CO2 processing generates aqueous cisplatin with enhanced cancer specificity. ACS Omega 5, 4558−4567
Henning-Knechtel, A., Kumar, S., Wallin, C., Król, S., Wärmländer, S., Jarvet, J., Esposito, G., Kirmizialtin, A., Gräslund, A., Hamilton, A.D. & Magzoub, M.* Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity. Cell Rep. Phys. Sci. 1,100014.
-
English language press coverage: EurekAlert, Nature Asia, The National, Al Khaleej Today, Dubai PR Network, Go Dubai, Gulf Today, Medical Xpress, Newsbreak, The National Tribune & Zawya.
-
Arabic language press coverage: 24.ae, 6060 News, Abu Dhabi News, Akhbarak, Al Bayan, Al Fajr, Al Ittihad, Al Khaleej, Al Shabiba, Al Sharq Times, Bawabaa News, Emaratyah,Gulf365, MenaFn,Miral news,Nabd, Radaar News & Synar.
2019
Kumar, S., Hamilton, A.D., Magzoub, M., Hassan, S. Use of oligopyridylamides to inhibit mutant p53 amyloid formation and restore its tumor suppressor function. US Patent 10,500,197.
Pansieri, J., Ostojić, L., Iashchishyn, I.A., Magzoub, M., Wallin, C., Wärmländer, S., Gräslund, A., Ngoc, M.N., Smirnovas, V., Svedruzic, Z. & Morozova-Roche, L.A. (2019) Pro-inflammatory S100A9 protein aggregation promoted by NCAM1 peptide constructs. ACS Chem. Biol. 14, 1410−1417.
Kalmouni, M., Al Hosani, S. & Magzoub, M.* Cancer targeting peptides. Cell Mol. Life Sci. 76, 2171-2183.
Nguyen, V.P., L. Palanikumar, Kennel, S.J., Ye, Y., Alves, D.S., Wall, J.S., Magzoub, M. & Barrera, F.N. Mechanistic insights into the pH-dependent membrane peptide ATRAM. J. Control. Release 298, 142-153.
2018
Kumar, S.*, Henning-Knechtel, A., Magzoub, M.* & Hamilton, A.D.* Peptidomimetic-based multi-domain targeting offers critical evaluation of Aβ structure and toxic function. J. Am. Chem. Soc. 140, 6562–6574.
Yanez, A., Desta, I., Commins, P., Magzoub, M. & Naumov, P. Morphokinematics of the hygroactuation of feather grass awns. Adv. Biosyst. 2, 1800007.
2017
Henning-Knechtel, A., Knechtel, J. & Magzoub, M.* DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels. Nucleic Acids Res. 45, 12057-12068.
Selected as a Breakthrough Article and a Cover Article.
Kumar, S., Henning-Knechtel, A., Chehade, I., Magzoub, M. & Hamilton, A.D. Foldamer-mediated structural rearrangement attenuates Aβ oligomerization and cytotoxicity. J. Am. Chem. Soc. 139, 17098-17108.
Woldetsadik, A.D., Sharma, S.K., Khapli, S., Jagannathan, R.* & Magzoub, M.* Hierarchically porous calcium carbonate scaffolds for bone tissue engineering. ACS Biomater. Sci. Eng. 3, 2457–2469.
Benyettou, F., Fahs, H., Elkharrag, R., Bilbeisi, R.A., Asma, B., Rezgui, R., Motte, L., Magzoub, M., Brandel, J., Olsen, J.-C., Piano, F., Gunsalus, K., Platas-Iglesias, C. & Trabolsi, A. Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. RSC Adv. 7, 23827–23834.
Woldetsadik, A.D., Vogel, M.C., Rabeh, W.M. & Magzoub, M.* Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells. FASEB J., 31, 2168-2184.
Sharma, S.K., Woldetsadik, A.D., Blanton, T., O’Connor, M.J., Magzoub, M.* & Jagannathan, R.* Production of nanostructured molecular liquids by supercritical CO2 processing. OpenNano 2, 9-18.
Mukundan, V., Maksoudian, C., Vogel, M.C., Chehade, I., Katsiotis, M.S., Alhassan, S.M. & Magzoub, M.* Cytotoxicity of prion protein-derived cell-penetrating peptides is modulated by pH but independent of amyloid formation. Archives Biochem. Biophys. 613, 31-42.
2016
Rezgui, R., Blumer, K., Yeoh-Tan, G., Trexler, A.J. & Magzoub, M. Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy. Biochim. Biophys. Acta 1858, 1499-1506.
2015
Benyettou, F., Rezgui, R., Ravaux, F., Jaber, T., Blumer, K., Jouiad, M., Motte, L., Olsen, J.-C., Platas-Iglesias, C., Magzoub, M. & Trabolsi, A. Synthesis of silver nanoparticles for the dual delivery of doxorubicin and alendronate to cancer cells. J. Mater. Chem. B 3, 7237-7245.
Kulikov, O.V., Kumar, S., Magzoub, M., Knipe, P.C., Saraogi, I., Thompson, S., Miranker, A.D. & Hamilton, A.D. Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation. Tetrahedron Lett. 56, 3760-3673.
2014
Hebda, J., Magzoub, M. & Miranker, A.D. Small molecule screening in context: Lipid-catalyzed amyloid formation. Protein Sci. 23, 1341-1348.
2012
Magzoub, M. & Miranker, A.D. Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide. FASEB J. 26, 1228-1238.
2011
Magzoub, M. & Miranker, A.D. p53 succumbs to peer pressure. Nat. Chem. Biol. 7, 248-249.
2009
Hebda, J.A., Saraogi, I., Magzoub, M., Hamilton, A.D. & Miranker, A.D. A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chem. Biol. 16, 943-950.
Magzoub, M., Zhang, H., Dix, J.A. & Verkman, A.S. Extracellular space volume measured by two-color pulsed dye injection with microfiberoptic fluorescence photodetection. Biophys. J. 96, 2382–2390.
2008
Zador, Z., Magzoub, M., Jin, S., Manley, G.T., Papadopoulos, M.C. & Verkman, A.S. Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space in brain. FASEB J. 22, 870-879.
Magzoub, M., Jin, S. & Verkman, A.S. Enhancement of macromolecule diffusion deep in tumors following enzymatic degradation of extracellular matrix collagen and its associated proteoglycan decorin. FASEB J. 22, 276-284.
Oglecka K., Lundberg, P., Magzoub, M., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Relevance of the N-terminal NLS-like sequence of the prion protein for membrane perturbation effects. Biochim. Biophys. Acta 1778, 206-213.
2006
Magzoub, M., Padmawar, P., Dix, J.A. & Verkman, A.S. Millisecond association kinetics of K+ with Triazacryptand-based K+ indicators measured with fluorescence correlation spectroscopy. J. Phys. Chem. B 110, 21216-21221.
Magzoub, M., Sandgren, S., Lundberg, P., Oglecka, K., Lilja, J., Wittrup, A., Eriksson, L.E.G., Langel, Ü., Belting, M. & Gräslund, A. N-terminal peptides from unprocessed prion proteins enter cells by macropinocytosis. Biochem. Biophys. Res. Commun. 348, 379-385.
Thiagarajah, J.R., Kim, J.K., Magzoub, M. & Verkman, A.S. Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching. Nat. Methods 3, 275-280.
Magzoub, M., Gräslund, A. & Pramanik, A. Characterization of prion-derived cell-penetrating peptides in cellular and model membrane systems. In Biochemistry and Biophysics of Lipids (Pramanik, A., ed), pp. 175-192, Transworld Research Network, Kerala.
2005
Magzoub, M., Pramanik, A. & Gräslund, A. Modelling the endosomal escape of cell-penetrating peptides: transmembrane pH gradient driven translocation across phospholipid bilayers. Biochemistry 44, 14890-14897.
Magzoub, M., Oglecka, K., Pramanik, A., Eriksson, L.E.G. & Gräslund, A. Membrane perturbation effects by peptides derived from the N-termini of prion proteins. Biochim. Biophys. Acta 1716, 126-136.
2004
Magzoub, M. & Gräslund, A. Cell-penetrating peptides: from inception to application. Q. Rev. Biophys. 37, 147-195.
2003
Magzoub, M., Eriksson, L.E.G. & Gräslund, A. Comparison of the interaction, positioning, structure induction and membrane perturbation of cell-penetrating peptides and non-translocating variants with phospholipid vesicles. Biophys. Chem. 103, 271-288.
2002
Lundberg, P., Magzoub, M., Lindberg, M., Hällbrink, M., Jarvet, J., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Cell membrane translocation of the N-terminal (1-28) part of the prion protein. Biochem. Biophys. Res. Commun. 299, 85-90.
Magzoub, M., Eriksson, L.E.G. & Gräslund, A. Conformational states of the cell-penetrating peptide penetratin when interacting with phospholipids vesicles: effects of surface charge and peptide concentration. Biochim. Biophys. Acta 1563, 53-63.
2001
Kilk, K., Magzoub, M., Pooga, M., Eriksson, L.E.G. Langel, Ü. & Gräslund, A. Cellular internalization of a cargo complex with a novel peptide derived from the third helix of the islet-1 homeodomain. Comparison with the penetratin peptide. Bioconjug. Chem. 12, 911-916.
Magzoub, M., Kilk, K., Eriksson, L.E.G., Langel, Ü. & Gräslund, A. Interaction and structure induction of cell-penetrating peptides in the presence of phospholipid vesicles. Biochim. Biophys. Acta 1516, 77-89.
Magzoub Lab
Experimental Research Building (ERB)
NYU Abu Dhabi
Saadiyat Island Campus
P.O. Box 129188
Abu Dhabi, United Arab Emirates
Contact:
Phone: +971 2 628 4760
Fax: +971 2 659 07 91