Journal Cover
Cucurbit[7]uril inhibits islet amyloid polypeptide aggregation by targeting N terminus hot segments and attenuates cytotoxicity
publications
L. Palanikumar*, Kalmouni, M., Houhou, T., Abdullah, O., Ali, L., Pasricha, R., Straubinger, R., Thomas, S., Afzal, A.J., Barrera, F.N. & Magzoub, M.* (2023) pH-responsive upconversion mesoporous silica nanospheres for combined multimodal diagnostic imaging and targeted photodynamic and photothermal cancer therapy. ACS Nano 19, 18979–18999.
https://doi.org/10.1021/acsnano.3c04564
Press coverage (Arabic): Al Khaleej, Mena FN, Nabd, Masr Al Youm, Head Topics, UAE News App, Emirate Press, 7enews
Press coverage (English): Khaleej Times, Gulf News, Reuters, Zawya, Zawya2, WAM, Emirati News, MSN, Wired, 7enews, ARN News Center, Big News Network, Tech Magazine, The Print
Behind the Paper: Kalmouni, M., L. Palanikumar & Magzoub, M. (2024) pH-responsive upconversion mesoporous silica nanospheres for enhanced phototherapy. Nature Cancer Research Community.
Venit, T., Sapkota, O., Abdrabou, W.S., Loganathan, P., Pasricha, R., Mahmood, S.R., El Said, N.H., Sherif, S., Thomas, S., Abdelrazig, S., Amin, S., Bedognetti, D., Idaghdour, Y., Magzoub, M. & Percipalle P. (2023) Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice. Nat. Commun. 14, 6328.
Maity, D., Oh, Y., Gremer, L., Hoyer, W., Magzoub, M. & Hamilton, A.D. (2022) Cucurbit[7]uril inhibits IAPP aggregation by targeting N-terminus hot segments. Chem. Eur. J. 28, e2022004.
https://doi.org/10.1002/chem.202200456
L. Palanikumar, Karpauskaite, L., Al-Sayegh, M., Alam, M., Chehade, I., Hassan, S., Maity, D., Ali, L., Falls, Z., Samudrala, R., Kalmouni, M., Hunashal, Y., Ahmed, J., Houhou, T., Karapetyan, S., Pasricha, R., Esposito, G., Afzal, A.J., Hamilton, A.D.*, Kumar, S.* & Magzoub, M.* (2021) Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat. Commun. 12, 3962.
https://doi.org/10.1038/s41467-021-23985-1
Press coverage (Arabic): WAM, Al Ittihad, Al Khaleej, Al Bayan, Al Roeya, Al Fajr, Al Wahda, AlWatan, Nabd1, Nabd2, Head Topics, Gulf Tourism, UrduPoint
Presscoverage (English): The National, WAM, Zawya, UrduPoint, Archyde, Eurek Alert, ScienMag
Behind the Paper: Kalmouni, M., L. Palanikumar & Magzoub, M. (2021) A functional bridge: amyloid inhibitors and cancer. Nature Cancer Research Community.
Maity, D., Howarth, M., Vogel, M.C., Magzoub, M. & Hamilton, A.D. (2021) Peptidomimetic-based Vesicles Inhibit Amyloid-β Fibrillation and Attenuate Cytotoxicity. J. Am. Chem. Soc. 143, 3086–3093.
https://doi.org/10.1021/jacs.0c09967
Alam, M., Tahir, J., Siddiqui, A., Magzoub, M., Shahzad-ul-Hussan, S., Mackey, D. & Afzal, A.J. (2021) RIN4 homologs from important crop species differentially regulate the Arabidopsis NB-LRR immune receptor, RPS2. Plant Cell Rep. 40, 2341–2356.
Maity, D., Kumar, S., AlHussein, R., Gremer, L., Howarth, M., Karpauskaite, L., Hoyer, W., Magzoub, M. & Hamilton, A.D. (2020) Sub-stoichiometric inhibition of IAPP aggregation: A peptidomimetic approach to anti-amyloid agents. RSC Chem. Biol. 1, 225-232.
https://doi.org/10.1039/D0CB00086H
L. Palanikumar, Al-Hosani, S., Kalmouni, M., Saleh, H. & Magzoub, M.* (2020) Hexokinase II-derived cell-penetrating peptide mediates delivery of microRNA mimic for cancer-selective cytotoxicity. Biochemistry 59, 2259−2273.
https://doi.org/10.1021/acs.biochem.0c00141
Behind the Paper: Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M.* (2020) Hexokinase II-derived cancer targeting peptide: a novel strategy to combat cancer. Nature Cancer Research Community.
Magzoub, M. (2020) Combating proteins with proteins: Engineering cell-penetrating peptide antagonists of amyloid-β aggregation and associated neurotoxicity. DNA Cell Biol. 39, 920–925.
https://doi.org/10.1089/dna.2020.5604
L. Palanikumar, Al-Hosani, S., Kalmouni, M., Nguyen, V.P., Ali, L., Pasricha, R., Barrera, F.N. & Magzoub, M.* (2020) pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. Biol. 3, 95.
https://doi.org/10.1038/s42003-020-0817-4
Selected as a Research Highlight.
Highlighted in the editorial 'Setting out on a fantastic voyage to advance nanomedicine'.
Press coverage (Arabic): 24.ae, Al Bayan, Al Fajr, Al Ittihad, Al Khaleej, Al Roeya
Press coverage (English): EurekAlert, The National, Abu Dhabi City Guide, ecancer, European Pharmaceutical Review, Expatmedia, Innovators Magazine, Medical Xpress, News Medical, Science Codex, Zawya
Behind the Paper: Kalmouni, M., L. Palanikumar, Al-Hosani, S. & Magzoub, M. (2020) Exploiting the unique properties of tumors to deliver chemotherapeutics to cancer cells. Nature Cancer Research Community.
Sharma, S.K.S., Al-Hosani, S., Kalmouni, M., Nair, A.R., Palanikumar, L., Pasricha, R., Sadler, K.C., Magzoub, M. & Jagannathan, R. (2020) Supercritical CO2 processing generates aqueous cisplatin with enhanced cancer specificity. ACS Omega 5, 4558−4567.
https://doi.org/10.1021/acsomega.9b03917
Henning-Knechtel, A., Kumar, S., Wallin, C., Król, S., Wärmländer, S., Jarvet, J., Esposito, G., Kirmizialtin, A., Gräslund, A., Hamilton, A.D. & Magzoub, M.* (2020) Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity. Cell Rep. Phys. Sci. 1,100014.
https://doi.org/10.1016/j.xcrp.2020.100014
Presss Coverage (Arabic): 24.ae, Akhbarak, Al Bayan, Al Fajr, Al Ittihad, Al Khaleej, Al Shabiba, Gulf365, MenaFn, Radaar News, Synar
Press coverage (English): EurekAlert, Nature Middle East, The National, Dubai PR Network, Go Dubai, Gulf Today, Medical Xpress, The National Tribune, Zawya
Pansieri, J., Ostojić, L., Iashchishyn, I.A., Magzoub, M., Wallin, C., Wärmländer, S., Gräslund, A., Ngoc, M.N., Smirnovas, V., Svedruzic, Z. & Morozova-Roche, L.A. (2019) Pro-inflammatory S100A9 protein aggregation promoted by NCAM1 peptide constructs. ACS Chem. Biol. 14, 1410−1417.
https://doi.org/10.1021/acschembio.9b00394
Kalmouni, M., Al Hosani, S. & Magzoub, M.* (2019) Cancer targeting peptides. Cell Mol. Life Sci. 76, 2171-2183.
https://doi.org/10.1007/s00018-019-03061-0
Nguyen, V.P., L. Palanikumar, Kennel, S.J., Ye, Y., Alves, D.S., Wall, J.S., Magzoub, M. & Barrera, F.N. (2019) Mechanistic insights into the pH-dependent membrane peptide ATRAM. J. Control. Release 298, 142-153.
Kumar, S.*, Henning-Knechtel, A., Magzoub, M.* & Hamilton, A.D.* (2018) Peptidomimetic-based multi-domain targeting offers critical evaluation of Aβ structure and toxic function. J. Am. Chem. Soc. 140, 6562–6574.
https://doi.org/10.1021/jacs.7b13401
Yanez, A., Desta, I., Commins, P., Magzoub, M. & Naumov, P. (2018) Morphokinematics of the hygroactuation of feather grass awns. Adv. Biosyst. 2, 1800007.
Henning-Knechtel, A., Knechtel, J. & Magzoub, M.* (2017) DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels. Nucleic Acids Res. 45, 12057-12068.
https://doi.org/10.1093/nar/gkx990
Selected as a Breakthrough Article.
Kumar, S., Henning-Knechtel, A., Chehade, I., Magzoub, M. & Hamilton, A.D. (2017) Foldamer-mediated structural rearrangement attenuates Aβ oligomerization and cytotoxicity. J. Am. Chem. Soc. 139, 17098-17108.
https://doi.org/10.1021/jacs.7b08259
Woldetsadik, A.D., Sharma, S.K., Khapli, S., Jagannathan, R.* & Magzoub, M.* (2017) Hierarchically porous calcium carbonate scaffolds for bone tissue engineering. ACS Biomater. Sci. Eng. 3, 2457–2469.
https://doi.org/10.1021/acsbiomaterials.7b00301
Benyettou, F., Fahs, H., Elkharrag, R., Bilbeisi, R.A., Asma, B., Rezgui, R., Motte, L., Magzoub, M., Brandel, J., Olsen, J.-C., Piano, F., Gunsalus, K., Platas-Iglesias, C. & Trabolsi, A. (2017) Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles. RSC Adv. 7, 23827–23834.
https://doi.org/10.1039/C7RA02693E
Woldetsadik, A.D., Vogel, M.C., Rabeh, W.M. & Magzoub, M.* (2017) Hexokinase II-derived cell-penetrating peptide targets mitochondria and triggers apoptosis in cancer cells. FASEB J., 31, 2168-2184.
https://doi.org/10.1096/fj.201601173R
Sharma, S.K., Woldetsadik, A.D., Blanton, T., O’Connor, M.J., Magzoub, M.* & Jagannathan, R.* (2017) Production of nanostructured molecular liquids by supercritical CO2 processing. OpenNano 2, 9-18.
https://doi.org/10.1016/j.onano.2016.11.001
Mukundan, V., Maksoudian, C., Vogel, M.C., Chehade, I., Katsiotis, M.S., Alhassan, S.M. & Magzoub, M.* (2017) Cytotoxicity of prion protein-derived cell-penetrating peptides is modulated by pH but independent of amyloid formation. Archives Biochem. Biophys. 613, 31-42.
https://doi.org/10.1016/j.abb.2016.11.001
Rezgui, R., Blumer, K., Yeoh-Tan, G., Trexler, A.J. & Magzoub, M. (2016) Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy. Biochim. Biophys. Acta 1858, 1499-1506.
Kulikov, O.V., Kumar, S., Magzoub, M., Knipe, P.C., Saraogi, I., Thompson, S., Miranker, A.D. & Hamilton, A.D. (2015) Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation. Tetrahedron Lett. 56, 3760-3673.
For a full list of publications, please visit this link.
Phone: +971 2 628 4760
Fax: +971 2 659 0791
Magzoub Lab
Experimental Research Building (ERB)
NYU Abu Dhabi
Saadiyat Island Campus
P.O. Box 129188
Abu Dhabi, United Arab Emirates
