The designed cell-penetrating peptides represent a novel potential treatment strategy for Alzheimer's disease
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Read some of the press coverage of our new paper, Designed cell-penetrating peptide inhibitors of amyloid-beta aggregation and cytotoxicity,  here or access the full list of publications.

Dr. Mazin Magzoub

Image: TOC figure for recently published paper. Background: MD simulations of CPP/amyloid-beta complexes.

Our Research

Our research spans and merges three fields: drug delivery strategies, amyloid diseases, and cancer therapeutics. Our collaborations, both within the United Arab Emirates and worldwide, expand and contextualize our research for broader applications.

Our students are also actively involved in designing and conducting their own research within these fields in their capstone projects. Learn more by clicking on the links below.

Background: Artistic representation of research targets.

Meet our Team 

Our team is a diverse group of post-docs, research assistants, instructors, and students. And one cactus.

 
 
 

LATEST Publications

Palanikumar, L., Al-Hosani, S., Kalmouni, M., Saleh, H. & Magzoub, M.* (2020) Hexokinase II-derived cell-penetrating peptide mediates delivery of microRNA mimic for cancer-selective cytotoxicity. Biochemistry 59, 2259−2273.

Magzoub, M. Combating Proteins with Proteins: Engineering cell-penetrating peptide antagonists of amyloid-β aggregation and associated neurotoxicity. DNA and Cell Biology 39920–925.

Selected as a Cover Article.

Palanikumar, L., Al-Hosani, S., Kalmouni, M., Nguyen, V.P., Ali, L., Pasricha, R., Barrera, F.N. & Magzoub, M.* (2020) pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. Biol. 3, 95.

Selected as a Research Highlight and a Cover Article.

Highlighted in the editorial "Setting out on a fantastic voyage to advance nanomedicine".

Sharma, S.K.S., Al-Hosani, S., Kalmouni, M., Nair, A.R., Palanikumar, L., Pasricha, R., Sadler, K.C., Magzoub, M. & Jagannathan, R. (2020) Supercritical CO2 processing generates aqueous cisplatin with enhanced cancer specificity. ACS Omega 5, 4558−4567.

Henning-Knechtel, A., Kumar, S., Wallin, C., Król, S., Wärmländer, S., Jarvet, J., Esposito, G., Kirmizialtin, A., Gräslund, A., Hamilton, A.D. & Magzoub, M.* (2020) Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity. Cell Rep. Phys. Sci. 1,100014.

Pansieri, J., Ostojić, L., Iashchishyn, I.A., Magzoub, M., Wallin, C., Wärmländer, S., Gräslund, A., Ngoc, M.N., Smirnovas, V., Svedruzic, Z. & Morozova-Roche, L.A. (2019) Pro-inflammatory S100A9 protein aggregation promoted by NCAM1 peptide constructs. ACS Chem. Biol. 14, 1410−1417. 

Kalmouni, M., Al Hosani, S. & Magzoub, M.* (2019) Cancer Targeting Peptides. Cell Mol. Life Sci. 76, 2171-2183.

Nguyen, V.P., Palanikumar, L., Kennel, S.J., Ye, Y., Alves, D.S., Wall, J.S., Magzoub, M. & Barrera, F.N. (2019) Mechanistic insights into the pH-dependent membrane peptide ATRAM. J. Control. Release 298, 142-153.

Background: Small molecule inhibitors of amyloid-beta, designed and created by Khulood Alawadi, NYUAD.

 

Recent News

April 30, 2020: Our paper, pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics, has been highlighted in the editorial Setting out on a fantastic voyage to advance nanomedicine.

March 31, 2020: Laura has been selected for the competitive and prestigious NYUAD Post-Graduation Research Fellowship. The Fellowship will fund Laura's highly exciting research project in the lab from September 2020 to August 2021. Congratulations Laura!

 

March 6, 2020: Mona posted a wonderful Behind-the-Paper blog, Exploiting the unique properties of tumors to deliver chemotherapeutics to cancer cells, to the Nature Research Cancer Community describing the story behind our recent publication in Communications Biology.

March 2020: Our paper, pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics, published in Communications Biology and selected as a Research Highlight and a Cover Article, received extensive press coverage.

February 2020: Our paper, Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity, published in Cell Reports Physical Science, received extensive press coverage.

February 15-19, 2020: Palani presented a poster, pH Responsive Upconversion Mesoporous Silica Nanoparticles for Targeted Photodynamic and Photothermal Cancer Therapy, at the 2020 Annual Biophysical Society Meeting in San Diego, CA.

January 12-14, 2020: Mazin gave a talk, Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity, at the 3rd NYU Biomedical and Biosystems Conference held at NYU Abu Dhabi.

The Magzoub Lab is part of the Biology Program at NYU Abu Dhabi.