Despite continuing advances in the development of macromolecules, e.g. proteins and oligonucleotides, for therapeutic purposes, the successful application of these largely hydrophilic molecules has so far been hampered by their inability to efficiently bypass the plasma membrane. Another major drawback hindering the successful application of these therapeutics is their lack of target specificity.
Our research team, based in NYU Abu Dhabi, is actively developing novel drug delivery systems – peptides, liposomes and nanoparticles – to enhance the targeting and cellular uptake of therapeutics in order to maximize their efficacy.
Background: Hybrid DNA and alpha-hemolysin pores, designed and created by Khulood Alawadi, NYUAD.
Our research spans and merges three fields: drug delivery strategies, amyloid diseases, and cancer therapeutics. Our collaborations, both within the United Arab Emirates and worldwide, expand and contextualize our research for broader applications.
Our students are also actively involved in designing and conducting their own research within these fields in their capstone projects. Learn more by clicking on the links below.
Background: Artistic representation of research targets.
Meet our Team
Our team is a diverse group of post-docs, research assistants, instructors, and students. And one cactus.
Kalmouni, M., Al Hosani, S. & Magzoub, M. Cancer Targeting Peptides. Cell Mol. Life Sci., in press.
Nguyen, V.P., Palanikumar, L., Kennel, S.J., Ye, Y., Alves, D.S., Wall, J.S., Magzoub, M. & Barrera, F.N. Mechanistic insights into the pH-dependent membrane peptide ATRAM. J. Control. Release, in press.
Kumar, S.*, Henning-Knechtel, A., Magzoub, M.* & Hamilton, A.D.* Peptidomimetic-based multi-domain targeting offers critical evaluation of Aβ structure and toxic function. J. Am. Chem. Soc. 140, 6562–6574.
Yanez, A., Desta, I., Commins, P., Magzoub, M. & Naumov, P. Morphokinematics of the hygroactuation of feather grass awns. Adv. Biosyst., 2, 1800007.
Henning-Knechtel, A., Knechtel, J. & Magzoub, M.* DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels. Nucleic Acids Res. 45, 12057-12068.
Selected as a Breakthrough Article and a Cover Article.
Kumar, S., Henning-Knechtel, A., Chehade, I., Magzoub, M. & Hamilton, A.D. Foldamer-mediated structural rearrangement attenuates Aβ oligomerization and cytotoxicity. J. Am. Chem. Soc. 139, 17098-17108.
Background: Amyloid beta targeting small molecules, designed and created by Khulood Alawadi, NYUAD.