The designed cell-penetrating peptides represent a novel potential treatment strategy for Alzheimer's disease
"
"
Read some of the press coverage of our new paper, Designed cell-penetrating peptide inhibitors of amyloid-beta aggregation and cytotoxicity, here or access the full list of publications.
Dr. Mazin Magzoub
Image: TOC figure for recently published paper. Background: MD simulations of CPP/amyloid-beta complexes.
Our Research
Our research spans and merges three fields: drug delivery strategies, amyloid diseases, and cancer therapeutics. Our collaborations, both within the United Arab Emirates and worldwide, expand and contextualize our research for broader applications.
Our students are also actively involved in designing and conducting their own research within these fields in their capstone projects. Learn more by clicking on the links below.
Background: Artistic representation of research targets.
Meet our Team
Our team is a diverse group of post-docs, research assistants, instructors, and students. And one cactus.
LATEST Publications
L. Palanikumar, Karpauskaite, L., Hassan, S., Alam, M., Al-Sayegh, M., Chehade, I., Maity, D., Ali, L., Falls, Z., Samudrala, R., Kalmouni, M., Hunashal, Y., Ahmed, J., Karapetyan, S., Pasricha, R., Esposito, G., Afzal, A.J., Hamilton, A.D.*, Kumar, S.* & Magzoub, M.* (2020) Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. bioRxiv.
Maity, D., Kumar, S., AlHussein, R., Gremer, L., Howarth, M., Karpauskaite, L., Hoyer, W., Magzoub, M. & Hamilton, A.D. (2020) Sub-stoichiometric inhibition of IAPP aggregation: A peptidomimetic approach to anti-amyloid agents. RSC Chem. Biol., in press.
Selected as a Cover Article.
L. Palanikumar, Al-Hosani, S., Kalmouni, M., Saleh, H. & Magzoub, M.* (2020) Hexokinase II-derived cell-penetrating peptide mediates delivery of microRNA mimic for cancer-selective cytotoxicity. Biochemistry 59, 2259−2273.
Magzoub, M. (2020) Combating Proteins with Proteins: Engineering cell-penetrating peptide antagonists of amyloid-β aggregation and associated neurotoxicity. DNA and Cell Biology 39, 920–925.
L. Palanikumar, Al-Hosani, S., Kalmouni, M., Nguyen, V.P., Ali, L., Pasricha, R., Barrera, F.N. & Magzoub, M.* (2020) pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Commun. Biol. 3, 95.
Selected as a Research Highlight and a Cover Article.
Highlighted in the editorial "Setting out on a fantastic voyage to advance nanomedicine".
Sharma, S.K.S., Al-Hosani, S., Kalmouni, M., Nair, A.R., Palanikumar, L., Pasricha, R., Sadler, K.C., Magzoub, M. & Jagannathan, R. (2020) Supercritical CO2 processing generates aqueous cisplatin with enhanced cancer specificity. ACS Omega 5, 4558−4567.
Henning-Knechtel, A., Kumar, S., Wallin, C., Król, S., Wärmländer, S., Jarvet, J., Esposito, G., Kirmizialtin, A., Gräslund, A., Hamilton, A.D. & Magzoub, M.* (2020) Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity. Cell Rep. Phys. Sci. 1,100014.
Background: Small molecule inhibitors of amyloid-beta, designed and created by Khulood Alawadi, NYUAD.
Recent News
April 30, 2020: Our paper, pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics, has been highlighted in the editorial Setting out on a fantastic voyage to advance nanomedicine.
March 31, 2020: Laura has been selected for the competitive and prestigious NYUAD Post-Graduation Research Fellowship. The Fellowship will fund Laura's highly exciting research project in the lab from September 2020 to August 2021. Congratulations Laura!
March 6, 2020: Mona posted a wonderful Behind-the-Paper blog, Exploiting the unique properties of tumors to deliver chemotherapeutics to cancer cells, to the Nature Research Cancer Community describing the story behind our recent publication in Communications Biology.
March 2020: Our paper, pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics, published in Communications Biology and selected as a Research Highlight and a Cover Article, received extensive press coverage.
-
English language press coverage: EurekAlert, The National, Abu Dhabi City Guide, Bio Portfolio, ecancer, European Pharmaceutical Review, Expatmedia, Coding Societies, Innovators Magazine, Medical Xpress, Nature Research, Nature Research Cancer Community, News Medical, Science Codex & Zawya.
-
Arabic language press coverage: 24.ae, Al Bayan, Al Fajr, Al Ittihad, Al Khaleej & Al Roeya.
February 2020: Our paper, Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity, published in Cell Reports Physical Science, received extensive press coverage.
-
English language press coverage: EurekAlert, Nature Asia, The National, Al Khaleej Today, Dubai PR Network, Go Dubai, Gulf Today, Medical Xpress, Newsbreak, The National Tribune & Zawya.
-
Arabic language press coverage: 24.ae, 6060 News, Abu Dhabi News, Akhbarak, Al Bayan, Al Fajr, Al Ittihad, Al Khaleej, Al Shabiba, Al Sharq Times, Bawabaa News, Emaratyah, Gulf365, MenaFn, Miral news, Nabd, Radaar News & Synar.
February 15-19, 2020: Palani presented a poster, pH Responsive Upconversion Mesoporous Silica Nanoparticles for Targeted Photodynamic and Photothermal Cancer Therapy, at the 2020 Annual Biophysical Society Meeting in San Diego, CA.
January 12-14, 2020: Mazin gave a talk, Designed cell-penetrating peptide inhibiters of amyloid-beta (Aβ) aggregation and cytotoxicity, at the 3rd NYU Biomedical and Biosystems Conference held at NYU Abu Dhabi.